ViewSizer 3000

Simultaneous Multi-Laser Nanoparticle Tracking Analysis (NTA)

Exosomes? Virus? Nanoparticle? Use multiple lasers for complete, detailed analysis of all the particles in your sample.

Exosomes, viruses, and nanoparticles all have wide size distributions which defeat traditional Nanoparticle Tracking Analysis (NTA) analyzers. The ViewSizer 3000 features simultaneous measurement with three lasers to collect the most accurate distribution and concentration information over a wide range of sizes within the same sample. Where the signal from a particle is too bright and saturates the detector from one laser, the software automatically uses data from a lower power laser to ensure the most accurate size and concentration information. On the other hand, when scattering from one laser is too weak for detection, the software uses data from a higher power laser to accurately track the particle.

Cross contamination is a concern in all analyses. Simplified cleaning means thorough cleaning. The easy-to-remove sample cells can be dissassembled for rapid, thorough cleaning, which leads to better data.

Escape the limits of traditional NTA

Accurate and sensitive analysis without cross contamination

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Manufacturing CompanyHORIBA Instruments Incorporated

The ViewSizer 3000 uses the latest advances in nanoparticle tracking analysis (NTA) to accurately determine particle properties!

Size Measurement Range: 10 nm to 15 microns depending on sample

The ViewSizer determines particle size and size distribution details by multi-laser nanoparticle tracking analysis (NTA). Multiple lasers enable analysis of a broad range of sizes in the same sample.

Concentration Measurement Range: 1E5 to 1E9 particles/mL

NTA can be used to count particles in the measurement volume. A patented method corrects for the effect of particle size on effective measurement volume.

No cross-contamination

The sample cell can be completely removed and dissassembled for complete cleaning. Disassembly, cleaning, and reassembly is faster than rinsing a flow cell. Furthermore, multiple cells can be used for faster throughput or assigned to various groups in a shared (core) facility.

Featured Publications for the ViewSizer 3000:

Biological characterization using protein crystal measurements
A lipase-independent pathway of lipid release and immune modulation by adipocytes
Application of a novel new multispectral nanoparticle tracking technique
Biophysical characterization of polydisperse liposomal adjuvant formulations
Characterisation of particles in solution – a perspective on light scattering and comparative technologies
Cyclodextrin Reduces Intravenous Toxicity of a Model Compound
Development and anti-Candida evaluation of the vaginal delivery system of … nanosuspension-loaded thermogel
Electrochemical sensor based on F,N-doped carbon dots decorated laccase for detection of catechol
Light scattering by pure water and seawater: the depolarization ratio and its variation with salinity
Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis
Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells
Multifunctional Nanocomposites Based on Liposomes and Layered Double Hydroxides Conjugated with Glycylsarcosine for Efficient Topical Drug Delivery to the Posterior Segment of the Eye
Particle size analysis of polydisperse liposome formulations with a novel multispectral advanced nanoparticle tracking technology
Review of nanoparticles in ultrapure water: definitions and current metrologies for detection and control
Spark erosion as a high-throughput method for producing bimodal nanostructured 316L stainless steel powder
Synthesis and Characterization of EGFR-Targeted Immunoporphysomes
Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions
Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles | Protocol (
Isolation and characterization of EV in Saliva of Children with Asthma
Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential
Skeletal muscle tissue secretes more extracellular vesicles than white adipose tissue and myofibers are a major source ex vivo but not in vivo
Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands
Purification of Cas9 – RNA Complexes by Ultrafiltration
Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications
Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration
Circulating Extracellular Vesicles From Septic Mice Induce Brain Inflammation via Mirna Cargo
Measurement Range 10 nm to 15 μm
Typical Sample Volume 350 µL to 2.5 mL
Typical Sample Concentration
(Sample dependent)
10^5 – 10^9 particles/mL
Sample Temperature Range
10° C to 50° C +/- 0.1° C
Dimensions 55 cm W x 66 cm D x 35 cm H
Weight 27 kg
Operational Environment 15° C to 30° C with < 85% RH

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